Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering. Issue 5 (4th October 2017)

• Record Type: Journal Article
• Authors: Matta‐Domjan, Brigitta; King, Alice; Totti, Stella; Matta, Csaba; Dover, George; Martinez, Patricia; Zakhidov, Anvar; La Ragione, Roberto; Macedo, Hugo; Jurewicz, Izabela; Dalton, Alan; Velliou, Eirini G.
• Is Part Of: Journal of biomedical materials research. Volume 106:Issue 5(2018)
• Page Start: 1637
• Page End: 1644
• Publication Date: 2017-10-04
• Subjects: biocompatible pristine carbon nanotube substrate -- pancreatic adenocarcinoma -- pancreatic cancer tissue engineering -- extracellular matrix; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.b.34012
• Languages: English
• ISSNs: 1552-4973

Abstract

Abstract: Novel synthetic biomaterials able to support direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi‐walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds—which are easily tuneable to form sheets/fibers—support growth, proliferation, and spatial organization of pancreatic cancer cells, indicating their great potential in cancer tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1637–1644, 2018.