Endomembrane remodeling in autophagic membrane formation. Issue 5 (4th May 2018)

• Record Type: Journal Article
• Authors: Zhang, Min; Wang, Yu; Ge, Liang
• Is Part Of: Autophagy. Volume 14:Issue 5(2018)
• Page Start: 918
• Page End: 920
• Publication Date: 2018-05-04
• Subjects: autophagosome -- autophagy -- COPII -- ER-exit sites -- ER-Golgi Intermediate compartment; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2018.1425053
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: Autophagosomal membrane sources generate autophagic membrane precursors, which later assemble into the double-membrane autophagosome. The key events happening on the membrane sources during autophagic membrane generation remain poorly characterized. Our previous work found the ER-Golgi intermediate compartment (ERGIC) as a membrane source for the phagophore, the precursor to the autophagosome. A relocation of the COPII machinery from the ER-exit sites (ERES) to the ERGIC generates vesicles for LC3 lipidation. In recent work, we made a further step by showing that a starvation-induced remodeling of ERES facilitates the relocation of COPII to the ERGIC and the generation of the autophagic membrane.