Injectable nano-structured silicon-containing hydroxyapatite microspheres with enhanced osteogenic differentiation and angiogenic factor expression. Issue 16 (November 2018)

• Record Type: Journal Article
• Authors: Sun, Wenjun; Zhou, Yuning; Zhang, Xinran; Xia, Wei; Xu, Yuanjin; Lin, Kaili
• Is Part Of: Ceramics international. Volume 44:Issue 16(2018)
• Page Start: 20457
• Page End: 20464
• Publication Date: 2018-11
• Subjects: Hydroxyapatite -- Microspheres -- Nano-structures -- Osteogenic differentiation -- Angiogenic factor expression -- Carriers; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2018.08.040
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: Injectable bioactive ceramics with excellent osteogenesis play important roles in bone regeneration field. In this study, we creatively fabricated the injectable nano-structured silicon-containing hydroxyapatite (Si-HAp) microspheres in diameter of 70–100 µm via hydrothermal treatment of calcium silicate (CaSiO3 ) microspheres in Na3 PO4 aqueous solution. The fabricated Si-HAp microspheres were constructed by nano-rods with a diameter of 100 nm and length up to 1.5 µm. Comparing with the pure HAp microspheres, the obtained nano-structured Si-HAp microspheres exhibited excellent protein loading properties and sustained protein release capacities. Most importantly, the Si-substitution could apparently enhance the proliferation, osteogenic differentiation and the genes expression of angiogenic factors of rat bone marrow mesenchymal stem cells (rBMSCs). These all indicated that the nano-structured Si-HAp microspheres fabricated via hydrothermal transformation method might be used as promising injectable bioactive biomaterials and drug deliveries for bone regeneration.