Identification of hepatitis B virus genotype I in Thailand. Issue 4 (8th November 2018)

• Record Type: Journal Article
• Authors: Holzmayer, Vera; Hance, Robert; Defechereux, Patricia; Grant, Robert; Kuhns, Mary C.; Cloherty, Gavin; Rodgers, Mary A.
• Is Part Of: Journal of medical virology. Volume 91:Issue 4(2019)
• Page Start: 717
• Page End: 721
• Publication Date: 2018-11-08
• Subjects: hepatitis B virus -- recombinant virus -- recombination -- virus classification; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.25346
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract : The rare hepatitis B virus genotype I (HBV‐I) classification includes complex A/G/C/U recombinants identified amongst the individuals from China, India, Laos, and Vietnam. Herein we report the first HBV‐I specimen from Thailand, with detectable HBsAg despite a 10–amino‐acid truncation. This HBV‐I genome has a similar recombinant pattern to reference strains, including a C region that branches basal to references, suggesting a premodern era recombination event gave rise to HBV‐I. With an average sequence divergence from other genotypes ranging from 7.66% (standard deviation [SD], 0.42%; C) to 14.27% (SD, 0.31%; H), this new genome supports the HBV‐I classification as a unique genotype.