Hair cortisol concentration in patients with active central serous chorioretinopathy is elevated – a pilot study. Issue 4 (22nd November 2018)

• Record Type: Journal Article
• Authors: Lenk, Janine; Sandner, Dirk; Schindler, Lena; Pillunat, Lutz E.; Matthé, Egbert
• Is Part Of: Acta ophthalmologica. Volume 97:Issue 4(2019)
• Page Start: e568
• Page End: e571
• Publication Date: 2018-11-22
• Subjects: central serous chorioretinopathy -- hair cortisol concentration -- pathogenesis -- retina; Ophthalmology -- Periodicals; 617.7005
• DOI: 10.1111/aos.13979
• Languages: English
• ISSNs: 1755-375X

Abstract

Abstract: Purpose: To investigate hair cortisol concentration (HCC), a biochemical correlate of long‐term cortisol output patterns, and its relationship to active central serous chorioretinopathy (CSC). Methods: Twenty‐six participants were included in this observational pilot study (11 patients with active CSC and 15 healthy controls). Hair cortisol concentrations (HCCs) were determined from 3 cm hair strands collected near the scalp from patients and controls as an index of cumulative cortisol secretion over the 3‐month period prior to hair sampling. Results: Patients with CSC exhibited higher HCCs (mean value: 20.14, 95% CI: 14.89–27.16 pg/mg) than healthy controls (mean value: 11.06, 95% CI: 8.63–14.22 pg/mg, p = 0.008). Group differences were not affected by relevant covariates (BMI, smoking status, sex). Conclusion: Patients with active CSC have increased HCC, supporting the fact that cortisol is a major player in CSC pathogenesis.