Serological evidence of human infection by bat orthoreovirus in Singapore. Issue 4 (28th November 2018)

• Record Type: Journal Article
• Authors: Uehara, Anna; Tan, Chee Wah; Mani, Shailendra; Chua, Kaw Bing; Leo, Yee Sin; Anderson, Danielle E; Wang, Lin‐Fa
• Is Part Of: Journal of medical virology. Volume 91:Issue 4(2019)
• Page Start: 707
• Page End: 710
• Publication Date: 2018-11-28
• Subjects: bat -- luciferase immunoprecipitation system (LIPS) -- orthoreovirus -- spillover -- virus neutralization test (VNT); Virology -- Periodicals; 616
• DOI: 10.1002/jmv.25355
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract: To determine whether Pteropine orthoreovirus (PRV) exposure has occurred in Singapore, we tested 856 individuals from an existing serum panel collected from 2005‐2013. After an initial screen with luciferase immunoprecipitation system and secondary confirmation with virus neutralization test, we identified at least seven individuals with specific antibodies against PRV in both assays. Our findings confirm that PRV spillover into human populations is relatively common in this region of the world.