The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery. (6th June 2017)

• Record Type: Journal Article
• Authors: Tarca, Adi L.; Fitzgerald, Wendy; Chaemsaithong, Piya; Xu, Zhonghui; Hassan, Sonia S.; Grivel, Jean‐Charles; Gomez‐Lopez, Nardhy; Panaitescu, Bogdan; Pacora, Percy; Maymon, Eli; Erez, Offer; Margolis, Leonid; Romero, Roberto
• Is Part Of: American journal of reproductive immunology. Volume 78:Number 3(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-06-06
• Subjects: amniocentesis -- cervical insufficiency -- cytokine -- macrophage inflammatory protein -- network analysis -- preterm birth; Human reproduction -- Immunological aspects -- Periodicals; 616.69206
• DOI: 10.1111/aji.12686
• Languages: English
• ISSNs: 1046-7408

Abstract

Abstract : Problem: To characterize the amniotic fluid (AF) inflammatory‐related protein (IRP) network in patients with a sonographic short cervix (SCx) and to determine its relation to early preterm delivery (ePTD). Method of study: A retrospective cohort study included women with a SCx (≤25 mm; n=223) who had amniocentesis and were classified according to gestational age (GA) at diagnosis and delivery (ePTD <32 weeks of gestation). Results: (i) In women with a SCx ≤ 22 1/7 weeks, the concentration of most IRPs increased as the cervix shortened; those with ePTD had a higher rate of increase in MIP‐1α, MCP‐1, and IL‐6 concentrations than those delivering later; and (ii) the concentration of most IRPs and the correlation between several IRP pairs were higher in the ePTD group than for those delivering later. Conclusion: Women with a SCx at 16‐22 1/7 weeks have a unique AF cytokine network that correlates with cervical length at diagnosis and GA at delivery. This network may aid in predicting ePTD.