Brain abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome: Evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging. Issue 3 (14th November 2018)

• Record Type: Journal Article
• Authors: Kimura, Yukio; Sato, Noriko; Ota, Miho; Shigemoto, Yoko; Morimoto, Emiko; Enokizono, Mikako; Matsuda, Hiroshi; Shin, Isu; Amano, Keiko; Ono, Hirohiko; Sato, Wakiro; Yamamura, Takashi
• Is Part Of: Journal of magnetic resonance imaging. Volume 49:Issue 3(2019)
• Page Start: 818
• Page End: 824
• Publication Date: 2018-11-14
• Subjects: chronic fatigue syndrome -- diffusional kurtosis imaging -- neurite orientation dispersion -- density imaging; Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.26247
• Languages: English
• ISSNs: 1053-1807

Abstract

Abstract : Background: Diffusional kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) metrics provide more specific information regarding pathological changes than diffusion tensor imaging (DTI). Purpose: To detect microstructural abnormalities in myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS) patients by using DKI and NODDI metrics. Study Type: Prospective. Population: Twenty ME/CFS patients and 23 healthy controls were recruited. Field Strength/Sequence: Three‐b value DWI (b‐values = 0, 1000, and 2000 sec/mm 2 ) and 3D T1 ‐weighted images were at 3.0T. Assessment: Mean kurtosis (MK), neurite density index (NDI), orientation dispersion index (ODI), fractional anisotropy (FA), and mean diffusivity (MD) were calculated. Statistical Testing: The two‐sample t ‐test analysis in SPM12 software was used to compare the differences between ME/CFS and control groups. Results: In the ME/CFS patients, we observed significant FA decreases in the genu of the corpus callosum and the anterior limb of the right internal capsule ( P < 0.05), but no significant difference in MD ( P = 0.164); there were also significant MK decreases in the right frontal area, anterior cingulate gyrus, superior longitudinal fasciculus (SLF), and left parietal area ( P < 0.05). Significant NDI decreases were observed in the right posterior cingulate gyrus, SLF, and left frontal area of the ME/CFS patients ( P < 0.05). Significant ODI decreases were seen in the bilateral occipital areas, right superior temporal gyrus, the anterior limb of internal capsule, and the posterior cingulate gyrus ( P < 0.05), and significant ODI increases were revealed in the bilateral occipital and right temporal areas ( P < 0.05). Data Conclusion: Right SLF abnormalities may be a diagnostic marker for ME/CFS. Level of Evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:818–824.