The Natural Growth Rate of Skull Base Meningiomas Compared With Non-Skull Base Meningiomas. Issue 4 (June 2019)

• Record Type: Journal Article
• Authors: Yao, Xiang; Wei, Ting; Zhang, Haoran; Li, Jialin; Tang, Aiwen; Ren, Ke
• Is Part Of: Journal of craniofacial surgery. Volume 30:Issue 4(2019)
• Publication Date: 2019-06
• Subjects: Growth rate -- meningioma -- meta-analysis -- non-skull base -- skull base; Facial bones -- Surgery -- Periodicals; Skull -- Surgery -- Periodicals; Face -- Surgery -- Periodicals; Surgery, Plastic -- Periodicals; 617.52
• DOI: 10.1097/SCS.0000000000005468
• Languages: English
• ISSNs: 1049-2275

Abstract

Abstract : Abstract: In the present study, the authors assessed the differences in natural growth rates between skull base and non-skull base meningiomas by meta-analysis. Studies investigating meningioma growth rate were compiled from PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature database, and the China National Knowledge Infrastructure databases. A systematic review and meta-analysis of the collected literature were conducted using Stata 12.0 software. A total of 7 observational cohort studies, including 361 patients with untreated meningiomas, were included in the study. Meta-analysis showed that the weighted mean difference for absolute growth rate (years), relative growth rate (years), and doubling time (month) were 0.42 (95% confidence interval [CI]: 0.20–0.64, P <.0001), 1.08 (95%CI: 0.85–1.32, P <.0001), and −0.56 [95%CI: (−0.78)–(−0.33), P <.0001)] respectively. These findings indicate that the natural growth rate of skull base meningioma is less than that of non-skull base meningioma. Abstract : Supplemental Digital Content is available in the text