Combined photodynamic therapy with systemic chemotherapy for unresectable cholangiocarcinoma. Issue 4 (13th January 2019)

• Record Type: Journal Article
• Authors: Gonzalez‐Carmona, Maria Angeles; Bolch, Maximilian; Jansen, Christian; Vogt, Annabelle; Sampels, Matthias; Mohr, Raphael U.; van Beekum, Katrin; Mahn, Robert; Praktiknjo, Michael; Nattermann, Jacob; Trebicka, Jonel; Branchi, Vittorio; Matthaei, Hanno; Manekeller, Steffen; Kalff, Jörg C.; Strassburg, Christian P.; Weismüller, Tobias J.
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 49:Issue 4(2019)
• Page Start: 437
• Page End: 447
• Publication Date: 2019-01-13
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.15050
• Languages: English
• ISSNs: 0269-2813

Abstract

Summary: Background: Chemotherapy with gemcitabine and cisplatin is the current standard for patients with unresectable cholangiocarcinoma. Local photodynamic therapy has also demonstrated benefit in patients with extrahepatic cholangiocarcinoma. Aim: To evaluate the benefit of photodynamic therapy in combination with systemic chemotherapy in advanced extrahepatic cholangiocarcinoma. Methods: Three hundred and fifty‐three patients diagnosed with cholangiocarcinoma between 2004 and 2016 were treated at the University Hospital of Bonn, Germany. Of these, 96 suffering from unresectable extrahepatic cholangiocarcinoma were included. Patients were stratified according to treatment: combination photodynamic therapy and chemotherapy (36 patients), photodynamic therapy alone (34 patients), and chemotherapy alone (26 patients). Results: Combined photodynamic therapy with chemotherapy resulted in significantly longer overall survival than chemotherapy alone ( P = 0.022). Median survival was 20 months in the combination group (95% CI: 16.38‐23.62), 15 months in the photodynamic alone group (95% CI: 10.02‐19.98) and 10 months in the chemotherapy alone group (95% CI: 8.45‐11.55). In multivariate analysis, combination therapy and photodynamic therapy alone (HR: 0.41, 95% CI: 0.22‐0.77, P = 0.006), metal stenting, and radiofrequency ablation were independent predictors of longer survival. Conclusions: Combination photodynamic therapy and chemotherapy was well tolerated and resulted in significantly longer survival than chemotherapy alone. Application of photodynamic therapy significantly correlated with longer survival, demonstrating benefit in advanced cholangiocarcinoma. Thus, photodynamic therapy should be considered during therapeutic decision making in advanced cholangiocarcinoma. Abstract : Linked Content This article is linked to Srinivasa and Wigmore and Gonzalez‐Carmona et al papers. To view these articles visit https://doi.org/10.1111/apt.15093 and https://doi.org/10.1111/apt.15134 .