Berberine as a potential autophagy modulator. Issue 9 (15th February 2019)

• Record Type: Journal Article
• Authors: Mohammadinejad, Reza; Ahmadi, Zahra; Tavakol, Shima; Ashrafizadeh, Milad
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 9(2019:Sep.)
• Page Start: 14914
• Page End: 14926
• Publication Date: 2019-02-15
• Subjects: autophagy -- berberine -- drug‐resistant -- pharmacognosy -- programmed cell death; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.28325
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Today, pharmacognosy is considered a valuable science in the prevention and treatment of diseases. Among herbals, Berberine is an isoquinoline alkaloid found in the Berberis species. Surprisingly, it shows antimicrobial, antiviral, antidiarrheal, antipyretic, and anti‐inflammatory potential. Furthermore, it diminishes drug resistance in cancer therapy and enhances tumor suppression in part through autophagy and cell cycle arrest mechanisms. In the present review, we discuss the effect of berberine on diverse cellular pathways and describe how berberine acts as an autophagy modulator to adjust physiologic and pathologic conditions and diminishes drug resistance in cancer therapy. Abstract : Among herbals, Berberine is an isoquinoline alkaloid found in the Berberis species. Furthermore, it diminishes drug resistance in cancer therapy and enhances tumor suppression in part through autophagy and cell cycle arrest mechanisms.