Investigation of the Hemodynamics Influencing Emboli Trajectories Through a Patient-Specific Aortic Arch Model. Issue 6 (June 2019)

• Record Type: Journal Article
• Authors: Malone, Fiona; McCarthy, Eugene; Delassus, Patrick; Buhk, Jan-Hendrick; Fiehler, Jens; Morris, Liam
• Is Part Of: Stroke. Volume 50:Issue 6(2019)
• Publication Date: 2019-06
• Subjects: aorta -- atrial fibrillation -- embolism -- hemodynamics -- stroke; Cerebrovascular disease -- Periodicals; Cerebral circulation -- Periodicals; 616.81
• DOI: 10.1161/STROKEAHA.118.023581
• Languages: English
• ISSNs: 0039-2499

Abstract

Abstract : Background and Purpose—: Cardiogenic emboli account for 15% to 20% of acute ischemic stroke cases worldwide. However, the chance of such emboli, of varying sizes, causing a stroke under various flow types has not been evaluated. Methods—: A patient-specific aortic arch model was fabricated from a medical image dataset of a 77-year-old male case, with atrial fibrillation and distal occlusion of the right M1 vessel. One hundred and eighty mammalian embolus analogs (EAs) were released one by one into the model under normal and atrial fibrillation flow conditions. A further 270 clots were fabricated using varying levels of thrombin (5–20 National Institutes of Health units thrombin). The effect of releasing several clots simultaneously was also examined by grouping EAs into 18 multiples of 5, 4, 3, and 2 clots, resulting in 504 EAs released. Results—: EAs with a length of ⩽10 mm were the most common geometry to travel through the common carotid arteries (44%); however, longer clots also traveled through these narrow vessels. Twenty two percent of EAs ranged from 10–20mm in length, 27% from 20–30mm and 7% were >30 mm in length. Higher density clots increased the propensity for clots to travel along the cerebral vessels ( P <0.05). Releasing more clots during each test, increased the probability of at least one clot traveling through an aortic arch branching vessel. Conclusions—: Embolus trajectory through the branching vessels of the aortic arch is not exclusively dependent on embolus size. EAs tend to travel proportionally with outlet flow rates, with a greater chance of a stroke caused by multiple breakaway emboli. Abstract : Supplemental Digital Content is available in the text.