Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis. (27th April 2016)

• Record Type: Journal Article
• Authors: Xiao, Bi-huan; Shi, Meihui; Chen, Hongqiang; Cui, Shaoshan; Wu, Yan; Gao, Xing-Hua; Chen, Hong-Duo
• Other Names: Parsad Davinder Academic Editor.
• Is Part Of: BioMed research international. Volume 2016(2016)
• Publication Date: 2016-04-27
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2016/3029810
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Abnormality of glutathione peroxidase (GPx) is involved in the etiology and pathogenesis of vitiligo. However, the results were controversial. Aim . The purpose of this meta-analysis is to compare the levels of GPx between vitiligo patients and healthy controls. Methods. Relevant published articles were searched according to eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% confidence interval (CI). Results. Twenty-three studies with a total of 1076 vitiligo patients and 770 healthy controls were included. The pooled meta-analysis showed that patients with vitiligo had equivalent levels of GPx with the healthy controls (SMD = −0.47, 95% CI: −1.03 to 0.08, and p = 0 . 095 ). Further subgroup analysis showed that the GPx levels of Asian patients or segmental vitiligo patients were, respectively, lower than those of healthy controls (Asian: SMD = −0.47, 95% CI: −1.08 to 0.14, and p = 0.0 01 ; segmental: SMD = −3.59, 95% CI: −6.38 to −0.80, and p = 0.012 ). Furthermore, the GPx levels in serum/plasma were significantly decreased in either stable or active vitiligo patients, comparing to healthy controls (stable: SMD = −2.01, 95% CI: −3.52 to −0.49, and p = 0.0 09 ; active: SMD = −2.34, 95% CI: −4.07 to −0.61, and p = 0 . 008 ). Conclusion . This meta-analysis showed a significant association between low GPx level and vitiligo.