Melanoma Explorer: a web application to allow easy reanalysis of publicly available and clinically annotated melanoma omics data sets. Issue 3 (June 2019)

• Record Type: Journal Article
• Authors: Strbenac, Dario; Wang, Kevin; Wang, Xinyue; Dong, Jiamin; Mann, Graham J.; Mueller, Samuel; Yang, Jean Y.H.
• Is Part Of: Melanoma research. Volume 29:Issue 3(2019)
• Publication Date: 2019-06
• Subjects: bioinformatics -- biomarkers -- patient survival; Melanoma -- Periodicals; Melanoma -- Periodicals; Melanomen; 616.99477
• DOI: 10.1097/CMR.0000000000000533
• Languages: English
• ISSNs: 0960-8931

Abstract

Abstract : Validating newly discovered biomarkers in large, publicly available data sets is often difficult and requires specialized computer programming skills. Melanoma Explorer is a web application that enables easy interrogation of melanoma omics data sets that are freely available in online data repositories with a point-and-click interface. Two use cases are demonstrated. First, the relationship of lysozyme mRNA expression is shown to be prognostic in two independent gene expression microarray data sets. Second, a figure from a journal article showing the relationship of tumour thickness and miR-382 abundance is reproduced. Melanoma Explorer is demonstrated to be a useful tool for reproducing results of published studies and providing additional evidence for biomarkers in independent data sets. Abstract : Supplemental Digital Content is available in the text.