5-HT1A autoreceptor in dorsal raphe nucleus mediates sensitization of conditioned place preference to cocaine in mice experienced with chronic pain. Issue 9 (12th June 2019)

• Record Type: Journal Article
• Authors: Li, Yongfeng; Zhu, Jianyu; Zheng, Qiaohua; Qian, Zhaoqiang; Zhang, Lizi; Wei, Chunling; Han, Jing; Liu, Zhiqiang; Ren, Wei
• Is Part Of: NeuroReport. Volume 30:Issue 9(2019)
• Publication Date: 2019-06-12
• Subjects: 5-HT1A autoreceptors -- chronic pain -- cocaine -- conditioned place preference -- dorsal raphe nucleus; Neurosciences -- Periodicals; Nervous system -- Periodicals; Neurophysiology -- Periodicals; Nervous System Diseases -- Periodicals; Nervous System Physiological Phenomena -- Periodicals; Neurosciences -- Periodicals; 616.805
• DOI: 10.1097/WNR.0000000000001260
• Languages: English
• ISSNs: 0959-4965

Abstract

Abstract : Chronic stress, including chronic neuropathic pain, cannot only induce depressive disorders but also enhance sensitization to addictive drugs. Ample evidence support the implication of the 5-hydroxytryptamine (5-HT) system in the enhanced sensitization to cocaine. However, mechanisms underpinning such an enhancement are still unclear. By using a neuropathic pain model and a combination of behavioral, neurochemical, and western blotting techniques, this study reveals that the mice experienced with chronic neuropathic pain express both depression-like disorders and significant conditioned place preference to cocaine. The conditioned place preference to cocaine and was abolished by administration of the 5-HT1A receptor antagonist into the dorsal raphe nucleus (DRN). The expression of DRN 5-HT1A receptor was upregulated in mice experienced with chronic neuropathic pain. Moreover, such an upregulation was restored by repeated exposure to cocaine. The results reveal that DRN 5-HT1A receptor mediate the sensitization to cocaine in mice experienced with chronic pain and may be used as a new molecular target for therapeutic interventions to drug addiction influenced by chronic stress.