Acceptability of a Novel Levofloxacin Dispersible Tablet Formulation in Young Children Exposed to Multidrug-resistant Tuberculosis. Issue 6 (June 2019)

• Record Type: Journal Article
• Authors: Purchase, Susan E.; Garcia-Prats, Anthony J.; De Koker, Petra; Draper, Heather R.; Osman, Muhammad; Seddon, James A.; Schaaf, H. Simon; Hesseling, Anneke C.
• Is Part Of: Pediatric infectious disease journal. Volume 38:Issue 6(2019)
• Publication Date: 2019-06
• Subjects: levofloxacin -- acceptability -- children -- resistant -- tuberculosis; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000002268
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Levofloxacin is used for the treatment and prevention of multidrug-resistant tuberculosis in children, but current adult formulations are poorly palatable. A questionnaire administered to caregivers of 27 children taking a novel 100 mg dispersible taste-masked levofloxacin tablet found the new formulation to be more palatable (69%) and easier to prepare (81%) than the adult formulation. This formulation may assist children to better adhere to anti-tuberculous therapy. Abstract : Supplemental Digital Content is available in the text.