Hilly or mountainous surface: a new CT feature to predict the behavior of pure ground glass nodules?. (2018)

• Record Type: Journal Article
• Authors: Borghesi, Andrea; Michelini, Silvia; Bertagna, Francesco; Scrimieri, Alessandra; Pezzotti, Stefania; Maroldi, Roberto
• Is Part Of: European journal of radiology open. Volume 5(2018)
• Page Start: 177
• Page End: 182
• Publication Date: 2018
• Subjects: Pure ground glass nodule -- Multidetector computed tomography -- Computer-assisted image analysis -- Quantitative histogram analysis -- Follow-up studies; Medical radiology -- Periodicals; 616.075705
• DOI: 10.1016/j.ejro.2018.09.004
• Languages: English
• ISSNs: 2352-0477

Abstract

Graphical abstract: Highlights: pGGNs typically show an indolent course with very slow growth rates. pGGNs exhibit different patterns of growth regardless of their initial CT features. Predicting the behavior of pGGNs on initial CT remains a diagnostic challenge. Diameter greater than 10 mm increases the risk of aggressive behavior in pGGNs. The analysis of surface morphology may help predict the behavior of pGGNs ≥ 10 mm. Abstract: Persistent pure ground-glass nodules (pGGNs) typically show an indolent course with very slow growth rates. These slow-growing lesions exhibit different growth patterns regardless of their initial computed tomography (CT) features. Therefore, predicting the aggressive behavior of pGGNs on initial CT remains a diagnostic challenge. The literature reports that computerized analysis and various quantitative features have been tested to improve the risk stratification for pGGNs. The present article describes the long-term follow-up of two pGGNs with different behavior and introduces, for the first time, a new computerized method of analysis that could be helpful for predicting the future behavior of pGGNs.