Indexing and mining large-scale neuron databases using maximum inner product search. (March 2017)

• Record Type: Journal Article
• Authors: Li, Zhongyu; Fang, Ruogu; Shen, Fumin; Katouzian, Amin; Zhang, Shaoting
• Is Part Of: Pattern recognition. Volume 63(2017:Mar.)
• Page Start: 680
• Page End: 688
• Publication Date: 2017-03
• Subjects: Neuron morphology -- Large-scale retrieval -- Binary coding; Pattern perception -- Periodicals; Perception des structures -- Périodiques; Patroonherkenning; 006.4
• DOI: 10.1016/j.patcog.2016.09.041
• Languages: English
• ISSNs: 0031-3203

Abstract

Abstract: Morphological retrieval is an effective approach to explore large-scale neuronal databases, as the morphology is correlated with neuronal types, regions, functions, etc. In this paper, we focus on the neuron identification and analysis via morphological retrieval. In our proposed framework, multiple features are extracted to represent 3D neuron data. Because each feature reflects different levels of similarity between neurons, we group features into different hierarchies to compute the similarity matrix. Then, compact binary codes are generated from hierarchical features for efficient similarity search. Since neuronal cells usually have tree-topology structure, it is hard to distinguish different types of neurons simply via traditional binary coding or hashing methods based on Euclidean distance metric and/or linear hyperplanes. Therefore, we employ an asymmetric binary coding strategy based on the maximum inner product search (MIPS), which not only makes it easier to learn the binary coding functions, but also preserves the non-linear characteristics of the neuron morphological data. We evaluate the proposed method on more than 17, 000 neurons, by validating the retrieved neurons with associated cell types and brain regions. Experimental results show the superiority of our approach in neuron morphological retrieval compared with other state-of-the-art methods. Moreover, we demonstrate its potential use cases in the identification and analysis of neuron characteristics from large neuron databases. Abstract : Graphical abstract: fx1 Highlights: A comprehensive and effective framework is designed to index and mine large-scale neuron morphological databases. A novel retrieval method is proposed based on maximum inner product search and feature hierarchy. Its potential use cases are demonstrated for neuron identification and property analysis.