Lipid Droplet Metabolism during Dengue Virus Infection. Issue 8 (August 2018)

• Record Type: Journal Article
• Authors: Randall, Glenn
• Is Part Of: Trends in microbiology. Volume 26:Issue 8(2018)
• Page Start: 640
• Page End: 642
• Publication Date: 2018-08
• Subjects: autophagy -- lipophagy -- lipid droplets -- ubiquitin profiling; Microbiology -- Periodicals; Infection -- Periodicals; Virulence (Microbiology) -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Virulence -- Periodicals; Microbiologie -- Périodiques; Infection -- Périodiques; Virulence (Microbiologie) -- Périodiques; Infection; Microbiology; Virulence (Microbiology); 579
• DOI: 10.1016/j.tim.2018.05.010
• Languages: English
• ISSNs: 0966-842X

Abstract

Abstract : Dengue virus (DENV) induces a proviral selective autophagy targeting lipid droplets, termed lipophagy, that stimulates lipid metabolism. Zhang et al . gained mechanistic insight into this process, demonstrating that DENV NS4A/B binds unmodified AUP1 and promotes its translocation from lipid droplets to autophagosomes to drive the induction of lipophagy.