Phase II Feasibility Study of a Weight Loss Intervention in Female Breast and Colorectal Cancer Survivors (SWOG S1008). Issue 10 (11th September 2018)

• Record Type: Journal Article
• Authors: Greenlee, Heather; Lew, Danika L.; Hershman, Dawn L.; Newman, Vicky A.; Hansen, Lisa; Hartman, Sheri J.; Korner, Judith; Shi, Zaixing; Sardo Molmenti, Christine L.; Sayegh, Antoine; Fehrenbacher, Lou; Lo, Shelly; Klemp, Jennifer; Rinn, Kristine; Robertson, John M.; Unger, Joseph; Gralow, Julie; Albain, Kathy; Krouse, Robert; Fabian, Carol
• Is Part Of: Obesity. Volume 26:Issue 10(2018)
• Page Start: 1539
• Page End: 1549
• Publication Date: 2018-09-11
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.22269
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract: Objective: This study aimed to test the feasibility of a 12‐month weight loss intervention using telephone‐based counseling plus community‐situated physical activity (PA) in female breast cancer (BC) and colorectal cancer (CRC) survivors. Methods: This multisite cooperative group study enrolled sedentary, female, postmenopausal BC and CRC survivors with BMI ≥ 25 kg/m 2 to receive 12‐month fitness center memberships and telephone counseling encouraging 150 min/wk of PA and a 500‐kcal/ddecrease in energy intake. Feasibility criteria included accrual, adherence, and retention. Target weight loss was ≥ 5%. Results: Among 25 BC survivors, median baseline BMI was 37.2 (range: 27.7‐54.6), accrual occurred in 10 months, 60% and 28% met diet and exercise goals, 80% provided 12‐month measures, and average weight loss was 7.6% (95% CI: −3.9%, 19.2%). Among 23 CRC survivors, median BMI was 31.8 (range: 26.4‐48.7), accrual occurred in 24 months, 61% and 17% met diet and exercise goals, 87% provided measures, and average weight loss was 2.5% (95% CI: −8.2%, 13.3%). Conclusions: It is feasible to recruit and retain BC survivors in a cooperative group diet and PA weight loss trial. BC survivors achieved clinically meaningful weight loss but did not meet a priori adherence goals. In CRC survivors, recruitment was more difficult, and the intervention was less effective.