Bimetal‐Catalyzed Cascade Reaction for Efficient Synthesis of N‐Isopropenyl 1, 2, 3‐Triazoles via In‐Situ Generated 2‐Azidopropenes. Issue 12 (21st May 2019)

• Record Type: Journal Article
• Authors: Liu, Zhenhua; Hao, Wenjing; Liu, Zhixian; Gao, Wen; Zhang, Zhihai; Zhang, Yanan; Li, Xiang; Tong, Lili; Tang, Bo
• Is Part Of: Chemistry, an Asian journal. Volume 14:Issue 12(2019)
• Page Start: 2149
• Page End: 2154
• Publication Date: 2019-05-21
• Subjects: 1, 2, 3-triazoles -- alkynes -- bimetal-catalyzed -- click reaction -- vinyl azides; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201900402
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: A bimetal‐catalyzed cascade reaction for the synthesis of N ‐isopropenyl 1, 2, 3‐triazoles in high yield is reported. This reaction involves the generation of 2‐azidopropenes in situ by C(sp 3 )‐OAr bond cleavage for click reaction and features a broad substrate scope, good functional group tolerance and readily available substrates. Abstract : A bimetal‐catalyzed cascade reaction for the synthesis of N ‐isopropenyl 1, 2, 3‐triazoles in high yield is described. This reaction involves the generation of 2‐azidopropenes in situ by C(sp 3 )‐OAr bond cleavage for click reaction, which eliminated the explosive risk of azides, and was achieved with broad substrate scope, good functional group tolerance and readily available substrates