Synthesis and Docking Study of Pyrimidine Derivatives Scaffold for Anti‐Hypertension Application. Issue 20 (28th May 2019)

• Record Type: Journal Article
• Authors: Katouah, Hanadi A.; Gaffer, Hatem. E.
• Is Part Of: ChemistrySelect. Volume 4:Issue 20(2019)
• Page Start: 6250
• Page End: 6255
• Publication Date: 2019-05-28
• Subjects: Antihypertensive -- Prazosin -- Structure activity relationship -- Sulfonamide; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201900799
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: The present work introduces four new macromolecules pyrrolo[2, 3‐ d ]pyrimidine scaffolds substituted with various benzene‐sulfonamide moieties; those were picked up via cyclization of 2‐amino‐3‐cyanopyrroles with phenyl isothiocyanate. The newly prepared pyrrolopyrimidine derivatives have been elucidated by spectroscopic techniques (FT‐IR, 1 HNMR, 13 CNMR and MS) and elemental analyses. The antihypertensive activity of the synthesized pyrrolopyrimidine derivatives based on sulfonamide moiety was evaluated. All pyrrolopyrimidine derivatives were showed a potent antihypertensive activity than Prazosin that utilized as standard drug. The structure activity relationship (SAR) was studied to correlate the influence of sulfonamide group with the aminopyrimidine moiety. Molecular docking for the synthesized derivatives and theoretical statistics were carried out to expect their antihypertensive efficacy. Abstract : Simple approach for synthesis and docking of new pyrrolopyrimidine derivatives toward antihypertensive activity was performed. The docking results were promoted us to apply these derivatives for in vivo antihypertensive activity study. All pyrrolopyrimidine derivatives were showed a comparable activity with Prazosin that utilized as standard drug.