Cancer screening. (February 2020)

• Record Type: Journal Article
• Authors: Sikora, Karol
• Is Part Of: Medicine. Volume 48:Number 2(2020)
• Page Start: 132
• Page End: 137
• Publication Date: 2020-02
• Subjects: Breast -- cancer detection -- cervical cancer -- colon -- lung -- MRCP -- prostate; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Médecine factuelle -- Périodiques; Medicine; Periodicals; Electronic journals; Electronic journals; 610
• DOI: 10.1016/j.mpmed.2019.11.013
• Languages: English
• ISSNs: 1357-3039

Abstract

Abstract: Cancer screening is a source of much debate. At the interface between public health, specialist care, economics and public health policy, it creates tensions between professional groups, politicians, the media and the public. A screening test may be cheap, but applying it to a population (with rigorous quality control and effective downstream processing of patients with abnormal results) creates a huge workload and cost. Screening can also have profound psychological effects. People with false-positive results require investigation yet are usually eventually found not to have cancer. Unless screening can be shown to reduce mortality from specific cancers, the resources used are better spent on improving care, and this has led to disparities in screening recommendations between countries. Advances in understanding the genetic basis of cancer are likely to provide new approaches to cancer risk assessment and new challenges for developing screening strategies, by risk-banding populations based on polymorphisms in low-penetrance cancer risk genes. The American Cancer Society guidelines for cancer screening, reviewed annually, represent a global gold standard that is difficult to emulate in most healthcare economies because of cost and under-capacity for downstream processing of abnormal findings. Tailoring cancer screening recommendations to a country's health economy is an essential public health intervention.