Chronic myelomonocytic leukemia as a transformation from polycythemia vera. (2019)

• Record Type: Journal Article
• Authors: Andrei, Mirela; Pandey, Anita; Avezbakiyev, Boris; Wang, Jen Chin
• Is Part Of: Leukemia research reports. Volume 11(2019)
• Page Start: 14
• Page End: 16
• Publication Date: 2019
• Subjects: Chronic myelomonocytic leukemia -- Polycythemia vera -- Monocytosis; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2019.03.004
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: The hallmark of Polycythemia vera (PV) is the presence of JAK2 V617F mutation and increased RBC mass. Chronic myelomonocytic leukemia (CMML) is defined as persistent blood absolute monocyte count (AMC) >/= 1 × 10 9 /L for at least 3 months with myeloid cell dysplasia. Few cases of evolved CMML from PV have been described. We present a case of PV that progressed to CMML. We demonstrated the CMML clone was most likely derived from PV- JAK2 V617F clone. This clone carried a complex genetic mutations of ASXL1, RUNX1, SRSF2 and TET2, NRAS, KRAS, plus CMML cells were of the classical phenotype CD14 + CD16 − by flow cytometry.