A strategy for strong interface bonding by 3D bioprinting of oppositely charged κ-carrageenan and gelatin hydrogels. (15th October 2018)

• Record Type: Journal Article
• Authors: Li, Huijun; Tan, Yu Jun; Li, Lin
• Is Part Of: Carbohydrate polymers. Volume 198(2018)
• Page Start: 261
• Page End: 269
• Publication Date: 2018-10-15
• Subjects: Bioprinting -- Hydrogel -- Interface -- Gelatin -- κ-carrageenan; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2018.06.081
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: A promising strategy for improving adhesion between 3D printed layers of hydrogel. Strong interface bonding between two oppositely charged hydrogels layers. The limitations of utilizing gelatin for bioprinting at 37 °C are overcome. Abstract: A promising approach for improving the interfacial bonding of a three-dimensionally (3D) printed multilayered structure has been investigated by taking advantage of the electrostatic interactions between two hydrogels with oppositely charges. Here, two hydrogels namely gelatin and κ-carrageenan, which are the cationic and anionic hydrogels respectively, are used. It is found that the interfacial bonding strength between these two oppositely charged hydrogels is significantly higher than that of a bilayered gelatin or a bilayered κ-carrageenan. The bioprinted multilayered κ-carrageenan-gelatin hydrogel construct demonstrates a very good biocompatibility and a good structure integrity at 37 °C. Our strategy also overcomes the limitation of using gelatin for bio-fabrication at 37 °C, without further post crosslinking.