Successful outcome of second allogeneic bone marrow transplantation for blastic plasmacytoid dendritic cell neoplasm with MYC locus rearrangement. (2019)

• Record Type: Journal Article
• Authors: Kato, Takeharu; Itonaga, Hidehiro; Taguchi, Jun; Makiyama, Junya; Fujioka, Machiko; Taguchi, Masataka; Horai, Makiko; Sawayama, Yasushi; Niino, Daisuke; Imaizumi, Yoshitaka; Hata, Tomoko; Yoshida, Shinichiro; Sakamoto, Kana; Takeuchi, Kengo; Ohshima, Koichi; Miyazaki, Yasushi
• Is Part Of: Leukemia research reports. Volume 11(2019)
• Page Start: 31
• Page End: 33
• Publication Date: 2019
• Subjects: Blastic plasmacytoid dendritic cell neoplasm -- Allogeneic hematopoietic stem cell transplantation -- Donor change -- MYC rearrangement; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2019.04.005
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: A 62-year-old male was diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN) with a MYC rearrangement. Four months after the first unrelated bone marrow transplantation (BMT), he developed the relapsed BPDCN. After the achievement of partial remission following re-induction therapy, he underwent a second BMT from another unrelated donor, and experienced complete remission with grade II acute graft-versus-host disease and moderate chronic graft-versus-host disease. He remains alive in complete remission more than 71 months after the second BMT. These results suggested that donor change at the second transplantation may represent a considerable therapeutic option for patients with relapsed BPDCN.