Shoring up DNA methylation and H3K27me3 domain demarcation at developmental genes. (22nd November 2017)

• Record Type: Journal Article
• Authors: Meehan, Richard R; Pennings, Sari
• Is Part Of: EMBO journal. Volume 36:Number 23(2017)
• Page Start: 3407
• Page End: 3408
• Publication Date: 2017-11-22
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201798498
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract : Mutual antagonism between DNA methylation and H3K27me3 histone methylation suggests a dynamic crosstalk between these epigenetic marks that could help ensure correct gene expression programmes. Work from Manzo et al (2017 ) now shows that an isoform of de novo DNA methyltransferase DNMT3A provides specificity in the system by depositing DNA methylation at adjacent "shores" of hypomethylated bivalent CpG islands (CGI) in mouse embryonic stem cells (mESCs). DNMT3A1‐directed methylation appears to be instructive in maintaining the H3K27me3 profile at the hypomethylated bivalent CGI promoters of developmentally important genes. Abstract : A specific isoform of de novo DNA methyltransferase DNMT3A acts on the "shores" of hypomethylated CpG islands at bivalent promoters.