Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations. Issue 43 (23rd September 2019)

• Record Type: Journal Article
• Authors: Manzanares-Palenzuela, C. Lorena; Pourrahimi, Amir M.; Gonzalez-Julian, J.; Sofer, Zdenek; Pykal, Martin; Otyepka, Michal; Pumera, Martin
• Is Part Of: Chemical science. Volume 10:Issue 43(2019)
• Page Start: 10010
• Page End: 10017
• Publication Date: 2019-09-23
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9sc03049b
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : MXenes show differential affinity towards single- and double-stranded DNA, with unique kinetics and potential for fluorescent biosensing. Abstract : The integration of nucleic acids with nanomaterials has attracted great attention from various research communities in search of new nanoscale tools for a range of applications, from electronics to biomedical uses. MXenes are a new class of multielement 2D materials baring exciting properties mostly directed to energy-related fields. These advanced materials are now beginning to enter the biomedical field given their biocompatibility, hydrophilicity and near-infrared absorption. Herein, we elucidate the interaction of MXene Ti3 C2 T x with fluorophore-tagged DNA by fluorescence measurements and molecular dynamics simulations. The system showed potential for biosensing with unequivocal detection at picomole levels and single-base discrimination. We found that this material possesses a kinetically unique entrapment/release behavior, with potential implications in time-controlled biomolecule delivery. Our findings present MXenes as platforms for binding nucleic acids, contributing to their potential for hybridization-based biosensing and related bio-applications.