Clinical Characteristics and Treatment of 308 Panuveitis Patients over 10 Years: Results from the KKESH Uveitis Survey Study Group. (17th November 2019)

• Record Type: Journal Article
• Authors: Arevalo, J. Fernando; Lasave, Andres F.; Gupta, Vishali; Kozak, Igor; Al Shamsi, Hanan Nasser; Al Suliman, Sulaiman Mohammad; Al Rushood, Abdulaziz Adel; Al-Zahrani, Yahya A.; Al-Mahmood, Ammar M.; Al Dhibi, Hassan A.
• Is Part Of: Ocular immunology and inflammation. Volume 27:Number 8(2019)
• Page Start: 1296
• Page End: 1304
• Publication Date: 2019-11-17
• Subjects: Panuveitis -- presumed intraocular tuberculosis -- uveitis -- Vogt–Koyanagi–Harada (VKH) disease; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2018.1523436
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To describe the clinical characteristics and surgical outcomes of panuveitis over a 10-year period. Methods : Data were collected on panuveitis etiology, treatment, surgery and change in vision. Results : Overall, 308 patients (594 eyes) were evaluated, 54.9% with non-granulomatous and 45.1% with granulomatous uveitis. Fifty-four patients had infectious and 254 had non-infectious uveitis. In infectious panuveitis, vision remained unchanged at last visit. The most frequent diagnosis was presumed intraocular tuberculosis (PIOTB) uveitis (48.1%). In the non-infectious subgroup vision increased significantly by 2 lines at last visit ( p = 0.020). The most common diagnose was Vogt–Koyanagi–Harada (VKH) disease (38.6%). Initial therapy was oral prednisone in 86.6% with non-infectious etiology followed by immunosuppressive agents. Surgery secondary to complications (mainly cataracts) was performed in 46.7% patients. Conclusion : In Saudi Arabia, panuveitis was mainly due to VHK. PIOTB was the most common etiology for infectious panuveitis. Immunosuppressive therapy and surgery maintained BCVA in non-infectious panuveitis.