Stereoselective total synthesis of paecilomycin E and F and its two congeners Cochliomycin C and 6-epi-Cochliomycin C. Issue 14 (18th July 2018) - Kadari, Sudhakar
Abstract: An efficient and concise approach to the total synthesis of Paecilomycins E (1 ) and F (2 ), Cochliomycin C (4 ) and 6-epi-Cochliomycin C (3 ) is described. The synthesis involves novel route to the synthesis of Paecilomycin E and F and further conversion to Cochliomycin C and 6-epi-Cochliomycin C. Olefin metathesis and base promoted macro lactonization being the key reactions followed by chlorination to achieve target Cochliomycin C and 6-epi-Cochliomycin C. Graphical Abstract: