Impaired Fasting Glucose in Nondiabetic Range: Is It a Marker of Cardiovascular Risk Factor Clustering?. (4th October 2015)

• Record Type: Journal Article
• Authors: Valentino, Giovanna; Kramer, Verónica; Orellana, Lorena; Bustamante, María José; Casasbellas, Cinthia; Adasme, Marcela; Salazar, Alejandra; Navarrete, Carlos; Acevedo, Mónica
• Other Names: Persichilli Silvia Academic Editor.
• Is Part Of: Disease markers. Volume 2015(2015)
• Publication Date: 2015-10-04
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2015/804739
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Background . Impaired fasting glucose (IFG) through the nondiabetic range (100–125 mg/dL) is not considered in the cardiovascular (CV) risk profile. Aim . To compare the clustering of CV risk factors (RFs) in nondiabetic subjects with normal fasting glucose (NFG) and IFG. Material and Methods . Cross-sectional study in 3739 nondiabetic subjects. Demographics, medical history, and CV risk factors were collected and lipid profile, fasting glucose levels (FBG), C-reactive protein (hsCRP), blood pressure (BP), anthropometric measurements, and aerobic capacity were determined. Results . 559 (15%) subjects had IFG: they had a higher mean age, BMI, waist circumference, non-HDL cholesterol, BP, and hsCRP (p < 0.0001 ) and lower HDL (p < 0.001 ) and aerobic capacity (p < 0.001 ). They also had a higher prevalence of hypertension (34% versus 25%;p < 0.001 ), dyslipidemia (79% versus 74%;p < 0.001 ), and obesity (29% versus 16%;p < 0.001 ) and a higher Framingham risk score (8% versus 6%;p < 0.001 ). The probability of presenting 3 or more CV RFs adjusted by age and gender was significantly higher in the top quintile of fasting glucose (≥98 mg/dL; OR = 2.02; 1.62–2.51). Conclusions . IFG in the nondiabetic range is associated with increased cardiovascular RF clustering.