Human Epidermal Growth Factor Receptor 2 Status in Gastric Carcinomas with Distinctive Prevalent Cribriform Component. (18th February 2018)

• Record Type: Journal Article
• Authors: Ieni, Antonio; Angelico, Giuseppe; Barresi, Valeria; Giuffrè, Giuseppe; Arena, Francesco; Caruso, Rosario Alberto; Tuccari, Giovanni
• Other Names: Angeletti Silvia Academic Editor.
• Is Part Of: Disease markers. Volume 2018(2018)
• Publication Date: 2018-02-18
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2018/1505428
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Objectives . A cribriform architectural pattern has been reported in 9% of one unselected consecutively collected series of gastric carcinomas (GC) with unfavourable prognostic outcome. Taking into consideration the biological relevance of the human epidermal growth factor receptor 2 (HER2) status, we have analyzed a cohort of GC with a cribriform component more than 40% (CGC) to evaluate the HER2 amplification rate as a potential target for therapy with trastuzumab. Results . HER2 overexpression was encountered in 21 of 100 (21%) GC; a progressive increase in HER2 amplification was appreciated moving from non-CGC (20.6%) towards CGC cases (21.6%), although this difference does not reach a statistical significance. Nevertheless, either in univariate or in multivariate analyses, stage and HER2 status showed a significantp value (<0.001) in CGC patients. Conclusions . Our data confirmed a worse prognosis in all CGC patients with HER2 amplification, resulting in a shorter survival time. We invite all pathologists in their daily practice to specify the occurrence of cribriform neoplastic component in GC, either in surgical or in bioptical samples, taking into practical assessment the high HER2 overexpression rate in order to correctly treat these patients with worse behavior.