PROM and Labour Effects on Urinary Metabolome: A Pilot Study. (4th February 2018)

• Record Type: Journal Article
• Authors: Meloni, Alessandra; Palmas, Francesco; Barberini, Luigi; Mereu, Rossella; Deiana, Sara Francesca; Fais, Maria Francesca; Noto, Antonio; Fattuoni, Claudia; Mussap, Michele; Ragusa, Antonio; Dessì, Angelica; Pintus, Roberta; Fanos, Vassilios; Melis, Gian Benedetto
• Other Names: Sapin Vincent Academic Editor.
• Is Part Of: Disease markers. Volume 2018(2018)
• Publication Date: 2018-02-04
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2018/1042479
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Since pathologies and complications occurring during pregnancy and/or during labour may cause adverse outcomes for both newborns and mothers, there is a growing interest in metabolomic applications on pregnancy investigation. In fact, metabolomics has proved to be an efficient strategy for the description of several perinatal conditions. In particular, this study focuses on premature rupture of membranes (PROM) in pregnancy at term. For this project, urine samples were collected at three different clinical conditions: out of labour before PROM occurrence (Ph1), out of labour with PROM (Ph2), and during labour with PROM (Ph3). GC-MS analysis, followed by univariate and multivariate statistical analysis, was able to discriminate among the different classes, highlighting the metabolites most involved in the discrimination.