Candidate Urine Peptide Biomarkers for IgA Nephropathy: Where Are We Now?. (21st January 2018)

• Record Type: Journal Article
• Authors: Marek-Bukowiec, Karolina; Konieczny, Andrzej; Ratajczyk, Krzysztof; Witkiewicz, Wojciech
• Other Names: Turck Natacha Academic Editor.
• Is Part Of: Disease markers. Volume 2018(2018)
• Publication Date: 2018-01-21
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2018/5205831
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Early detection, prognosis, and management of IgA nephropathy (IgAN) remain a challenge. Histological examination of renal tissue still comprises the only way to confirm an IgAN diagnosis. It is of great importance to establish noninvasive diagnostic, prognostic, and predictive biomarkers that would improve the clinical care and outcome of patients suffering from IgAN. This review summarises the findings from previous mass spectrometry- (MS-) based studies dedicated to the discovery of urinary peptide profiles specific to IgAN. There is a substantial number of urinary peptides that have been discovered to date, which show promise as biomarkers of IgAN; however, all of them require further, rigorous validation in well-planned studies, involving a large number of subjects who represent diverse and numerous populations.