Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children. (1st August 2018)

• Record Type: Journal Article
• Authors: de Oliveira, Rodrigo Mota; Figueiredo, Camylla Vilas Boas; Santiago, Rayra Pereira; Yahouédéhou, Sètondji Cocou Modeste Alexandre; Carvalho, Suéllen Pinheiro; da Paz, Silvana Souza; Fiuza, Luciana Magalhães; de Miranda, Fernando Nunes; da Guarda, Caroline Conceição; Fonseca, Cleverson Alves; Aleluia, Milena Magalhães; Barbosa, Cynara Gomes; Adorno, Elisângela Vitória; Gonçalves, Marilda de Souza
• Other Names: Angeletti Silvia Academic Editor.
• Is Part Of: Disease markers. Volume 2018(2018)
• Publication Date: 2018-08-01
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2018/9078939
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Background . The nonracial leukopenia may be a result of exposure to polycyclic derivatives (benzene-toluene-xylene (BTX)) and may arise from a possible change in the bone marrow microenvironment. The present study sought to evaluate the association of genetic polymorphisms in xenobiotic-metabolizing enzymes with hematological and biochemical profiles. Methods . We evaluated 89 African descendant children, exposed indirectly to benzene derivatives. Laboratory parameters were investigated by automated methods and genetic polymorphisms by PCR-RFLP and PCR multiplex. Results . Children with leukopenia had significantly decreased white blood cells (WBCs) and platelet counts, which is not consistent with benign leukopenia. In the same group, we have found that carriers of the CYP2E1 variant allele had decreased WBC and lymphocytes. Those with NQO1 variant allele had decreased WBC, neutrophil, eosinophil, monocyte, and lymphocyte counts. Carriers of the MPO variant allele had decreased WBC, neutrophil, eosinophil, basophil, monocyte, lymphocyte, and platelet counts and an elevated free iron level. Children with GSTT and GSTM null exhibited decreased WBC, neutrophil, basophil, and lymphocyte counts. Our multivariate analysis model reveals that females were independently associated with leukopenia. Conclusion . Our results suggest that the polymorphisms investigated were associated with hematological changes in the studied population. These alterations could be heightened by exposure to benzene derivatives.