Plasmonic‐Nanopore Biosensors for Superior Single‐Molecule Detection. Issue 23 (3rd April 2019)

• Record Type: Journal Article
• Authors: Spitzberg, Joshua D.; Zrehen, Adam; van Kooten, Xander F.; Meller, Amit
• Is Part Of: Advanced materials. Volume 31:Issue 23(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-04-03
• Subjects: biosensors -- DNA sequencing -- electro‐optical sensing -- light enhancement -- nanopores -- plasmonics -- single‐molecule sensing; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201900422
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Plasmonic and nanopore sensors have separately received much attention for achieving single‐molecule precision. A plasmonic "hotspot" confines and enhances optical excitation at the nanometer length scale sufficient to optically detect surface–analyte interactions. A nanopore biosensor actively funnels and threads analytes through a molecular‐scale aperture, wherein they are interrogated by electrical or optical means. Recently, solid‐state plasmonic and nanopore structures have been integrated within monolithic devices that address fundamental challenges in each of the individual sensing methods and offer complimentary improvements in overall single‐molecule sensitivity, detection rates, dwell time and scalability. Here, the physical phenomena and sensing principles of plasmonic and nanopore sensing are summarized to highlight the novel complementarity in dovetailing these techniques for vastly improved single‐molecule sensing. A literature review of recent plasmonic nanopore devices is then presented to delineate methods for solid‐state fabrication of a range of hybrid device formats, evaluate the progress and challenges in the detection of unlabeled and labeled analyte, and assess the impact and utility of localized plasmonic heating. Finally, future directions and applications inspired by the present state of the art are discussed. Abstract : Hybridizing plasmonic and nanopore structures enables superior single‐molecule sensing. A plasmonic nanopore sensor actively funnels and serially threads analytes through a molecular‐scale aperture aligned with an optical hotspot, wherein they are electro‐optically interrogated. The phenomena and sensing principles of plasmonic nanopores, enabling fabrication methods, and recent examples of devices are discussed.