Unfolded protein response‐mediated modulation of mesenchymal stem cells. Issue 2 (24th August 2019)

• Record Type: Journal Article
• Authors: Tavasolian, Fataneh; Hosseini, Ahmad Z.; Mirzaei, Ali; Abdollahi, Elham; Jandaghi, Pouria; Soudi, Sara; Naderi, Mahmood; Saburi, Ehsan; Momtazi‐Borojeni, Amir Abbas; Johnston, Thomas P.; Sahebkar, Amirhossein
• Is Part Of: IUBMB life. Volume 72:Issue 2(2020)
• Page Start: 187
• Page End: 197
• Publication Date: 2019-08-24
• Subjects: endoplasmic reticulum -- mesenchymal stem cells -- protein folding -- unfolded protein response; Biochemistry -- Periodicals; Molecular biology -- Periodicals; 572.8
• DOI: 10.1002/iub.2154
• Languages: English
• ISSNs: 1521-6543

Abstract

Abstract: The endoplasmic reticulum (ER) receives unfolded proteins predestined for the secretory pathway or to be incorporated as transmembrane proteins. The ER has to accommodate the proper folding and glycosylation of these proteins and also to properly incorporate transmembrane proteins. However, under various circumstances, the proteins shuttling through the ER can be misfolded and undergo aggregation, which causes activation of the unfolded protein response (UPR). The UPR is mediated through three primary pathways: activating transcription factor‐6, inositol‐requiring enzyme‐1 (IRE1), and PKR‐like endoplasmic reticulum kinase, which up‐regulate ER folding chaperones and temporarily suppress protein translation. The UPR can be both cytoprotective and/or cytotoxic depending on the duration of UPR activation and the type of host cell. Proteostasis controls stem cell function, while stress responses affect stem cell identity and differentiation. The present review aimed to explore and discuss the effects of the UPR pathways on mesenchymal stem cells.