The interplay among psychopathology, personal resources, context‐related factors and real‐life functioning in schizophrenia: stability in relationships after 4 years and differences in network structure between recovered and non‐recovered patients. Issue 1 (10th January 2020)

• Record Type: Journal Article
• Authors: Galderisi, Silvana; Rucci, Paola; Mucci, Armida; Rossi, Alessandro; Rocca, Paola; Bertolino, Alessandro; Aguglia, Eugenio; Amore, Mario; Bellomo, Antonello; Bozzatello, Paola; Bucci, Paola; Carpiniello, Bernardo; Collantoni, Enrico; Cuomo, Alessandro; Dell'Osso, Liliana; Di Fabio, Fabio; di Giannantonio, Massimo; Gibertoni, Dino; Giordano, Giulia Maria; Marchesi, Carlo; Monteleone, Palmiero; Oldani, Lucio; Pompili, Maurizio; Roncone, Rita; Rossi, Rodolfo; Siracusano, Alberto; Vita, Antonio; Zeppegno, Patrizia; Maj, Mario
• Other Names: Catapano Francesco investigator.; Piegari Giuseppe investigator.; Aiello Carmen investigator.; Brando Francesco investigator.; Giuliani Luigi investigator.; Pietrafesa Daria investigator.; Papalino Marco investigator.; Mercadante Giovanni investigator.; Di Palo Piergiuseppe investigator.; Barlati Stefano investigator.; Deste Giacomo investigator.; Valsecchi Paolo investigator.; Pinna Federica investigator.; Olivieri Benedetta investigator.; Manca Daniela investigator.; Signorelli Maria Salvina investigator.; Fusar Poli Laura investigator.; De Berardis Domenico investigator.; Fraticelli Silvia investigator.; Corbo Mariangela investigator.; Pallanti Stefano investigator.; Altamura Mario investigator.; Carnevale Raffaella investigator.; Malerba Stefania investigator.; Calcagno Pietro investigator.; Zampogna Domenico investigator.; Corso Alessandro investigator.; Giusti Laura investigator.; Salza Anna investigator.; Ussorio Donatella investigator.; Talevi Dalila investigator.; Socci Valentina investigator.; Pacitti Francesca investigator.; de Bartolomeis Andrea investigator.; Gramaglia Carla investigator.; Gambaro Eleonora investigator.; Gattoni Eleonora investigator.; Favaro Angela investigator.; Tenconi Elena investigator.; Meneguzzo Paolo investigator.; Tonna Matteo investigator.; Ossola Paolo investigator.; Gerra Maria Lidia investigator.; Carmassi Claudia investigator.; Cremone Ivan investigator.; Carpita Barbara investigator.; Girardi Nicoletta investigator.; Frascarelli Marianna investigator.; Buzzanca Antonio investigator.; Brugnoli Roberto investigator.; Comparelli Anna investigator.; Corigliano Valentina investigator.; Di Lorenzo Giorgio investigator.; Niolu Cinzia investigator.; Ribolsi Michele investigator.; Corrivetti Giulio investigator.; Cascino Giammarco investigator.; del Buono Gianfranco investigator.; Bolognesi Simone investigator.; Fagiolini Andrea investigator.; Goracci Arianna investigator.; Bellino Silvio investigator.; Montemagni Cristiana investigator.; Brasso Claudio investigator.;
• Is Part Of: World psychiatry. Volume 19:Issue 1(2020)
• Page Start: 81
• Page End: 91
• Publication Date: 2020-01-10
• Subjects: Schizophrenia -- network analysis -- real‐life functioning -- psychopathology -- personal resources -- internalized stigma -- recovery -- functional capacity -- everyday life skills; Psychiatry -- Periodicals; Mental illness -- Periodicals; 616.89005
• DOI: 10.1002/wps.20700
• Languages: English
• ISSNs: 1723-8617

Abstract

Abstract : Improving real‐life functioning is the main goal of the most advanced integrated treatment programs in people with schizophrenia. The Italian Network for Research on Psychoses previously explored, by using network analysis, the interplay among illness‐related variables, personal resources, context‐related factors and real‐life functioning in a large sample of patients with schizophrenia. The same research network has now completed a 4‐year follow‐up of the original sample. In the present study, we used network analysis to test whether the pattern of relationships among all variables investigated at baseline was similar at follow‐up. In addition, we compared the network structure of patients who were classified as recovered at follow‐up versus those who did not recover. Six hundred eighteen subjects recruited at baseline could be assessed in the follow‐up study. The network structure did not change significantly from baseline to follow‐up, and the overall strength of the connections among variables increased slightly, but not significantly. Functional capacity and everyday life skills had a high betweenness and closeness in the network at follow‐up, as they had at baseline, while psychopathological variables remained more peripheral. The network structure and connectivity of non‐recovered patients were similar to those observed in the whole sample, but very different from those in recovered subjects, in which we found few connections only. These data strongly suggest that tightly coupled symptoms/dysfunctions tend to maintain each other's activation, contributing to poor outcome in schizophrenia. Early and integrated treatment plans, targeting variables with high centrality, might prevent the emergence of self‐reinforcing networks of symptoms and dysfunctions in people with schizophrenia.