The multifaceted effects of metformin on tumor microenvironment. (February 2020)

• Record Type: Journal Article
• Authors: Kurelac, Ivana; Umesh Ganesh, Nikkitha; Iorio, Maria; Porcelli, Anna Maria; Gasparre, Giuseppe
• Is Part Of: Seminars in cell & developmental biology. Volume 98(2020)
• Page Start: 90
• Page End: 97
• Publication Date: 2020-02
• Subjects: AMPK AMP activated kinase -- Arg1 arginase -- BMDM bone marrow-derived macrophagesn -- CAFs cancer associated fibroblasts -- CI complex I -- HIF-1α hypoxia-inducible factor 1 alpha -- LPS lipopolysaccharide -- mTORC1 mammalian target of rapamycin complex I -- MDSC myeloid-derived suppressor cell -- NK natural killer cell -- PD-1 Programmed cell death protein 1 -- PD-L1 programmed death ligand 1 -- PMA phorbol myristate acetate -- TAM tumor associated macrophage -- TIL tumor infiltrating lymphocyte -- TME tumor microenvironment -- Treg regulatory T-cells; Cancer metabolism -- Metformin -- Respiratory complex I -- Tumor microenvironment -- Angiogenesis -- Cancer-associated fibroblasts -- Tumor-associated macrophages -- Cancer immunosuppression; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2019.05.010
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: The efficacy of metformin in treating cancer has been extensively investigated since epidemiologic studies associated this anti-diabetic drug with a lower risk of cancer incidence. Since tumors are complex systems, in which cancer cells coexist and interact with several different types of non-malignant cells, it is not surprising that anti-cancer drugs affect not only cancer cells, but also the abundance and functions of cells of the tumor microenvironment. Recent years have seen a wide collection of reports showing how metformin, as well as other complex I inhibitors, may influence cancer progression by modulating the phenotype of non-transformed cells in a tumor. In this review, we particularly focus on the effect of metformin on angiogenesis, cancer-associated fibroblasts, tumor-associated macrophages and cancer immunosuppression.