Utility of dual-energy CT for predicting the vascularity of meningiomas. Issue 123 (February 2020)

• Record Type: Journal Article
• Authors: Onishi, Shumpei; Fujioka, Chikako; Kaichi, Yoko; Amatya, Vishwa Jeet; Ishifuro, Minoru; Takeshima, Yukio; Awai, Kazuo; Sugiyama, Kazuhiko; Kurisu, Kaoru; Yamasaki, Fumiyuki
• Is Part Of: European journal of radiology. Issue 123(2020)
• Publication Date: 2020-02
• Subjects: BV blood volume -- CTDIvol volume CT dose index -- DECT dual energy CT -- DLP dose length product -- ED electron density -- FOV field of view -- PCT perfusion CT -- vWF von Willebrand factor -- Zeff effective atomic number Z; Meningioma -- Multidetector computed tomography -- Dual-energy CT -- Perfusion; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2019.108790
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: DECT parameters could predict the vascular density of meningiomas. Radiation exposure of DECT was much lower than that of PCT. DECT potentially could replace PCT for evaluating vascularity of meningiomas. Abstract: Purpose: Dual-energy computed tomography (DECT) can provide iodine, electron density (ED), and effective atomic number Z (Zeff ) maps, facilitating the identification of tissue types. We investigated whether DECT parameters can predict the vascularity of meningiomas. Method: We acquired DECT and perfusion CT (PCT) images in 24 patients with histologically diagnosed meningioma. Regions of interest (ROIs) were placed at the tumor in iodine, ED, and Zeff maps derived from DECT and in a blood volume (BV) map derived from PCT. To normalize these parameters' values, we divided them by the values of contralateral normal-appearing white matter, i.e., the relative (r)ED, rZeff, and rBV. The vascular density of the tumor specimens was immunohistochemically analyzed by calculating the von Willebrand factor-positive vessel wall. We calculated Pearson's correlation coefficients to determine the correlation with PCT/DECT parameters and an immunohistopathological index. Results: Contrast rZeff (r = 0.7020, p = 0.0001) and iodine (r = 0.5814, p = 0.0029) both had positive correlations with rBV derived from PCT. The rED values were negatively correlated with the rBV values (r = −0.4735, p = 0.0194), and the vascular density results confirmed positive correlations with rBV (r = 0.6909, p = 0.0002) and contrast rZeff (r = 0.4982, p = 0.0132) and a negative correlation with rED (r = −0.4265, p = 0.0377). Regarding the radiation exposure, the mean estimated volume CT dose index (CTDIvol ) of DECT was 33.1 ± 1.72 mGy, much lower than that of PCT (103.3 ± 4.65 mGy). Conclusions: DECT predicted vascular density with lower radiation exposure compared to PCT. DECT could potentially replace PCT for evaluating the vascularity of meningiomas.