Synthesis, characterization, and antioxidant and anticholinesterase activities of pyrazolo derivatives. (18th December 2019)

• Record Type: Journal Article
• Authors: Sicak, Yusuf; Oruç‐Emre, Emine E.; Öztürk, Mehmet; Karaküçük‐İyidoğan, Ayşegül; Nadeem, Said
• Is Part Of: Journal of heterocyclic chemistry. Volume 57:Number 2(2020)
• Page Start: 830
• Page End: 841
• Publication Date: 2019-12-18
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.3829
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract: Twenty‐four pyrazolo derivatives (1–4)(a‐f) were synthesized and characterized by FTIR, 1 H, and 13 C NMR (Nuclear Magnetic Resonance), and elemental analysis. The synthesized compounds were also investigated for their antioxidant and anticholinesterase activities. The compounds (3–4)(a‐f) carrying morpholine ring were more active than the piperidinyl containing compounds (1–2)(a‐f) in both activities. The compound 4f showed higher activity in both assays as compared with the others. Additionally, the anticholinesterase activity test provided higher values than the galantamine in the BChE assay. Therefore, compound 4f can be used as anticholinesterase agent and/or anticholinesterase assay standard. Abstract :