Facile Synthesis of Polysubstituted Indolizines via One‐Pot Reaction of 1‐Acetylaryl 2‐Formylpyrroles and Enals. Issue 3 (27th December 2019)

• Record Type: Journal Article
• Authors: Gong, Minghua; Guo, Jingcheng; Jiang, Pengrui; Zhang, Ye; Fu, Zhenqian; Huang, Wei
• Is Part Of: Chemistry, an Asian journal. Volume 15:Issue 3(2020)
• Page Start: 352
• Page End: 355
• Publication Date: 2019-12-27
• Subjects: [4+2] annulation -- dihydroindolizine -- indolizines -- pyridine-ring construction -- transition metal-free; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201901517
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: An efficient method for the synthesis of polysubstituted indolizines has been developed based on formal [4+2] annulation of 1‐acetylaryl 2‐formylpyrroles with enals, followed by oxidative aromatization. Pyridine‐type six‐membered rings were constructed in this transformation. This transition metal‐free reaction features mild reaction conditions, a broad substrate scope, and excellent functional group tolerance. Notably, the formyl group is well tolerated under reaction conditions. Abstract : An efficient method for the synthesis of polysubstituted indolizines is reported based on formal [4+2] annulation of 1‐acetylaryl 2‐formylpyrroles with enals, followed by oxidative aromatization. Pyridine‐type six‐membered rings were constructed in this transformation. This transition metal‐free reaction features mild reaction conditions, a broad substrate scope, and excellent functional group tolerance. Notably, the formyl group is well tolerated under reaction conditions.