Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics. (15th March 2020)

• Record Type: Journal Article
• Authors: Djekic, Ljiljana; Martinović, Martina; Ćirić, Ana; Fraj, Jadranka
• Is Part Of: Pharmaceutical development and technology. Volume 25:Number 3(2020)
• Page Start: 332
• Page End: 339
• Publication Date: 2020-03-15
• Subjects: Chitosan hydrogels -- microemulsion -- photon correlation spectroscopy -- rheological analysis -- ibuprofen -- sustained release; Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.1080/10837450.2019.1701495
• Languages: English
• ISSNs: 1083-7450

Abstract

Abstract: The physical chitosan hydrogel, obtained by ionic gelation in lactic acid solution, was combined with biocompatible oil-in-water microemulsion with ibuprofen, to prepare composite hydrogels with 0.25–1% of the polymer and 5% of the drug. The electrical conductivity measurement, photon correlation spectroscopy (PCS), and rheological analysis showed that the composite hydrogels comprise oil nanodroplets (16.21–22.56 nm) embedded within pseudoplastic chitosan hydrogel. In vitro ibuprofen release was sustained for 12 h and followed zero-order kinetics. pH values of the composite hydrogels were in the range of 4.80–5.27, thus physiologically acceptable. The formulation containing 0.5% chitosan enabled the maximum drug release rate of 239.25 μgh −1 cm −2 as well as cohesiveness (154.958 ± 0.731 g*s) higher than hardness (13.546 ± 0.065 g) and adhesiveness (−12.042 ± 1.161 g*s), so textural properties were suitable for application along skin surface, without spillage, and for easy removal. This is the first study in which the composite chitosan hydrogels with ibuprofen were formulated by combining the chitosan hydrogel prepared without harmful chemical crosslinkers and low viscosity oil-in-water microemulsion, and the preclinical characterization of their biopharmaceutical aspect and textural characterization, that is of key importance in improving the patient's compliance, were performed. Graphical Abstract: