A method for reduction of human ventricular action potential model. Issue 1 (2nd January 2020)

• Record Type: Journal Article
• Authors: Sabzpoushan, S. H.; Ghajarjazy, A.
• Is Part Of: Mathematical and computer modelling of dynamical systems. Volume 26:Issue 1(2020)
• Page Start: 1
• Page End: 30
• Publication Date: 2020-01-02
• Subjects: Model simplification -- human ventricular cell -- excitable dynamical systems; Engineering -- Mathematical models -- Periodicals; Computer simulation -- Periodicals; 515.39
• DOI: 10.1080/13873954.2019.1701039
• Languages: English
• ISSNs: 1387-3954

Abstract

ABSTRACT: Mathematical modelling and computer simulations are important tools in the field of cardiac electrophysiology. High computational costs of complex models make them difficult to apply in large-scale simulations like tissue. Therefore, model reduction are of particular importance in heart studies. In this paper, we introduce a technique for simplification of ventricular cell(VC) complex models. By using this technique, starting with a complex model of human VC including 17state variables, we reduce the number of state variables to two. Our simplified model is compared with the original one via several electrophysiological features and computational efficiency. Results show that the reduced model has acceptable behaviours in single cell and one-dimensional simulation, moreover, is 55 times faster than the original one. As the presented method does not depend on the reference model, it may be applied to every cardiac cell models or each complex excitable dynamical systems with the same dynamics as VC.