Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy. (17th February 2020)

• Record Type: Journal Article
• Authors: Carmo Corrêa, Deborah Elzita do; Maria Ayo, Christiane; Laguila Visentainer, Jeane Eliete; Ambrosio-Albuquerque, Eliane Papa; Guimarães Reis, Pâmela; Brandão de Mattos, Cinara Cássia; Bestetti, Reinaldo Bulgarelli; de Mattos, Luiz Carlos; Maria Sell, Ana
• Is Part Of: Platelets. Volume 31:Number 2(2020)
• Page Start: 272
• Page End: 275
• Publication Date: 2020-02-17
• Subjects: Chagas disease -- genetic association studies -- genotyping technique -- human platelet antigens -- SNPs; Blood platelets -- Periodicals; Blood Platelets -- Periodicals; 615.39
• DOI: 10.1080/09537104.2019.1667496
• Languages: English
• ISSNs: 0953-7104

Abstract

Abstract: Human platelet antigen (HPA) polymorphisms are considered to be a risk factor for cardiac and vascular diseases, but the role of HPA in chronic Chagas disease cardiomyopathy (CCC) is not available. Therefore, the aim of this study was to investigate the association of HPA polymorphisms, HPA-1, HPA-2, HPA-3, HPA-5 and HPA-15, in the severity of left ventricular systolic dysfunction (LVSD) in CCC patients. For this, 229 CCC patients were separated into three groups: without LVSD, mild/moderate LVSD and severe LVSD. PCR-SSP was performed for HPA genotyping and the risk was assessed using SNPStats software. HPA-1 allele and genotype frequencies were lower in mild/moderate LVSD patients compared to other groups, without statistical significance. After stratified analyzes, the HPA-3a/3b genotype frequency was lower in women with severe LVSD compared to those without LVSD (OR:0.29; 95% CI: 0.10–0.84). In conclusion, HPA-3 variant could be a protection factor for CCC in the female patients.