An atom-economical design of PET tracer for imaging αvβ3 integrin via utilizing the three-in-one function of 64Copper. Issue 12 (21st January 2020)

• Record Type: Journal Article
• Authors: Yang, Jing; Yang, Jian; Wang, Huan; Wang, Junfeng; Xiong, Jianping; Qiao, Chunhua; Ran, Chongzhao
• Is Part Of: Chemical communications. Volume 56:Issue 12(2020)
• Page Start: 1788
• Page End: 1791
• Publication Date: 2020-01-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc08690k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The αv β3 integrin in tumors was imaged with 64 Cu-Cyclo-RGD in which 64 Cu activated RGD peptide by cyclizing the pre-ligand GHRGDHG. Abstract : In this study, αv β3 integrin in U87 tumor cells was imaged with a 64 Cu-peptidic probe, in which the linear peptide GHRGDHG is used as a pre-ligand, while 64 Cu bears three functional roles that include generation of the PET signal, coordination with two GH moieties of the pre-ligand, and cyclizing the linear pre-ligand into an active cyclic-RGD form (termed as 64 Cu-Cyclo-RGD) for αv β3 integrin.