Strapped calix[4]pyrroles: from syntheses to applications. (20th January 2020)

• Record Type: Journal Article
• Authors: Peng, Sangshan; He, Qing; Vargas-Zúñiga, Gabriela I.; Qin, Lei; Hwang, Inhong; Kim, Sung Kuk; Heo, Nam Jung; Lee, Chang-Hee; Dutta, Ranjan; Sessler, Jonathan L.
• Is Part Of: Chemical Society reviews. Volume 49:Number 3(2020)
• Page Start: 865
• Page End: 907
• Publication Date: 2020-01-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cs00528e
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : Supramolecular chemistry is a central topic in modern chemistry. Abstract : Supramolecular chemistry is a central topic in modern chemistry. It touches on many traditional disciplines, such as organic chemistry, inorganic chemistry, physical chemistry, materials chemistry, environmental chemistry, and biological chemistry. Supramolecular hosts, inter alia macrocyclic hosts, play critical roles in supramolecular chemistry. Calix[4]pyrroles, non-aromatic tetrapyrrolic macrocycles defined by sp 3 hybridized meso bridges, have proved to be versatile receptors for neutral species, anions, and cations, as well as ion pairs. Compared to the parent system, octamethylcalix[4]pyrrole and its derivatives bearing simple appended functionalities, strapped calix[4]pyrroles typically display enhanced binding affinities and selectivities. In this review, we summarize advances in the design and synthesis of strapped calix[4]pyrroles, as well as their broad utility in molecular recognition, supramolecular extraction, separation technology, ion transport, and as agents capable of inhibiting cancer cell proliferation. Future challenges within this sub-field are also discussed.