The salt-free nickel-catalysed α-allylation reaction of ketones with allyl alcohol and diallylether. Issue 3 (22nd January 2020)

• Record Type: Journal Article
• Authors: Mouhsine, Bouchaib; Karim, Abdallah; Dumont, Clément; Sauthier, Mathieu
• Is Part Of: Green chemistry. Volume 22:Issue 3(2020)
• Page Start: 950
• Page End: 955
• Publication Date: 2020-01-22
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c9gc03619a
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : The alpha-allylation of ketones will allyl alcohol was performed thanks to the use of nickel-based catalysts. No base nor additive needed! Abstract : The nickel-catalysed α-allylation of ketones with allyl alcohol and diallylether has been performed under neutral conditions. As no base is involved, the products are synthesized without salts as side products. The dppf/Ni(cod)2 catalytic system in MeOH at 80 °C has been shown as the most effective reaction system to afford tetrasubstituted derivatives from various cyclic and acyclic ketones with one or two mobile protons. This process combined with a metathesis step yields spirocyclic compounds according to a salt free synthetic sequence.