Direct cyclopropanation of activated N-heteroarenes via site- and stereoselective dearomative reactions. Issue 6 (10th January 2020)

• Record Type: Journal Article
• Authors: Lee, Jiyoun; Ko, Donguk; Park, Hyunju; Yoo, Eun Jeong
• Is Part Of: Chemical science. Volume 11:Issue 6(2020)
• Page Start: 1672
• Page End: 1676
• Publication Date: 2020-01-10
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9sc06369b
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : A divergent cyclopropanation reaction has been accomplished via the dearomative addition of sulfur ylides to activated N-heteroarenes. Abstract : A divergent cyclopropanation reaction has been accomplished via the dearomative addition of sulfur ylides to activated N-heteroarenes. A series of biologically significant molecular skeletons was obtained by the direct cyclopropanation of quinolinium zwitterions. Furthermore, a straightforward synthetic route to optically enriched cyclopropane-fused heterocycles was developed using sulfur ylides as chiral nucleophiles in the 1, 4-dearomative reaction.