An oxidatively damaged G-quadruplex/hemin DNAzyme. Issue 12 (17th January 2020)

• Record Type: Journal Article
• Authors: Wang, Jiawei; Cheng, Mingpan; Chen, Jielin; Ju, Huangxian; Monchaud, David; Mergny, Jean-Louis; Zhou, Jun
• Is Part Of: Chemical communications. Volume 56:Issue 12(2020)
• Page Start: 1839
• Page End: 1842
• Publication Date: 2020-01-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc09237d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides clues to the mechanistic origins of DNAzyme deactivation. Abstract : Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides clues to the mechanistic origins of DNAzyme deactivation, which originates from an interplay between decreased G-quadruplex stability, lower hemin affinity and a modification of the nature of hemin binding sites.